Dextromethorphan
デキストロメトルファン
INN: Dextromethorphan
Antitussive (Non-narcotic)Published
Last updated: 3/14/2026
Mechanism of Action
JA日本語
延髄の咳中枢に直接作用し、咳反射を抑制します。コデインと異なり麻薬性がなく、依存性が低いとされています。NMDA受容体拮抗作用も有します。
ENEnglish
Acts directly on the cough center in the medulla oblongata to suppress the cough reflex. Unlike codeine, it is non-narcotic with low dependency potential. Also has NMDA receptor antagonist activity.
Efficacy & Effect Tags
Side Effects
JA日本語
眠気、めまい、悪心、便秘。大量摂取時に幻覚やセロトニン症候群のリスク。
ENEnglish
Drowsiness, dizziness, nausea, constipation. Risk of hallucinations and serotonin syndrome in overdose.
Contraindications
JA日本語
MAO阻害薬を服用中の患者。本剤の成分に対し過敏症の既往歴のある患者。
ENEnglish
Patients taking MAO inhibitors. Patients with a history of hypersensitivity to any component.